Impact of Topical v/s Systemic Steroids on Regaining Olfaction in Post Covid-19 Patients; A Randomized Controlled Trail

Background: Covid-19 is a spectrum of infection not only causing fever and respiratory changes but including alteration in chemosensory functions including; olfactory dysfunction gustatory dysfunction. In covid-19, dysregulation could be treated with either systemic steroids or topical steroids. Objective: To assess compare role regaining normal functions. Materials & Methods: A Randomized control trial was conducted at Central Park Teaching Hospital Lahore after getting ethical approval prior written informed consent from participants. total 35 patients were recruited segregated into two groups; Group 1 who (n=17) 2 given (n=18). Time frame regain olfaction compared between the groups using Mann Whitney U test. p value less than 0.05 considered as significant. Results: participants participated this randomized controlled mean ages 47.12 + 11.94 43.72 13.74 no significant difference. On appliance Mann-Whitney test group (52 39 v/s 4 2) it observed that steroid earlier to (topical steroids) .0001. Practical implication: Systemic Steroids will help prompt should part COVID-19 management. Conclusion: Olfaction management till covid-19 crucial yet unavoidable. play key early response so encouraged under physician observation. MeSH Words: Covid-19, olfaction, steroids, disorders, trial.